BIONOTE's Vcheck D-dimer, a More Sensitive Biomarker for Blood Clot Screening

 D-dimer diagnostic kit for quantitative results in-house


The sensitivity of BIONOTE's D-dimer kit, which can be used with the immunoassay analyzer Vcheck (V200 and V2400), has increased even more. 


During the secondary hemostasis of the blood clotting process, fibrin clots are produced, and they are degraded by plasmids into fibrin degradation products (FDP). D-dimer is one of the final degradation products of these processes and is considered a highly sensitive biomarker for coagulation activity.

The biomarker can be used to detect excessive thrombus formation early, which can aid in screening for diseases related to thrombus, such as thromboembolism (TE) or disseminated intravascular coagulation (DIC).

D-dimer can be clinically utilized by testing patients with risk factors that may cause thromboembolism such as cancer, sepsis, pancreatitis, vascular disease, or immune-mediated diseases. Furthermore, it can also be utilized for preemptively preventing emergencies after surgery or to monitor the progress and effectiveness of antithrombotic therapy.


A high correlation (R²=0.9289) was confirmed for the Vcheck measurements, in comparison with third-party analyzers with proven validity in canine D-dimer measurements, proving the Vcheck result's validity. 

A BIONOTE spokesperson stated, "The ability to screen for thrombus was improved by upgrading the performance (sensitivity) of the Vcheck D-dimer kit, which was first launched 5 years ago".

The Vcheck analyzer can measure a total of 30 biomarkers including inflammation markers (CRP, SAA), pancreatitis markers (cPL, fPL), cardiac disease markers (NT-proBNP, Troponin I), kidney disease markers (SDMA), hormones (T4, TSH, Cortisol), antibody titer tests, as well as D-dimer.