High immunogenicity following WSAVA guidelines, confirmed by Vcheck

 A paper using Vcheck CPV Ab testing has been published with results proving that regular vaccinations under the WSAVA guidelines increase the protection rate against parvovirus.


- [Related document] Evaluation materials 


Canine parvovirosis is a systemic disease caused by CPV-2 (canine parvovirus type 2). Typical symptoms of parvovirus include lack of appetite, vomiting, and bloody diarrhea.

The most effective way to prevent the parvovirus is prophylactic vaccination, and according to the WSAVA guidelines, it is recommended that booster vaccines be performed not more often than every 3 years after the initial puppy vaccination.


Based on the history of the vaccination against CPV, the study population was divided into three groups:


- Group I (n=59): Dogs regularly vaccinated against the disease according to WSAVA guidelines

- Group II (n=77): Dogs that completed the full course of CPV immunization as puppies but have not received a booster dose in the past three years

- Group III (n=64): Dogs that have not received vaccination against parvovirus in their lifetime


Statistical analysis showed a significantly greater number of dogs with high titers of antibodies against CPV of HI ≥ 80 in Group I (86%) compared to Group II (73%), and Group III (72%).


Table 1. Values of antibody titers in HI test for CPV in dogs in each group



Gender and race were not found to have an influence over the value of antibody titers against CPV.


Regular vaccinations by WSAVA recommendations increase protection against CPV, as evidenced by the lowest percentage of dogs with HI < 80 in Group I, which were regularly vaccinated at least every 3 years.


Additionally, the presence of dogs with high antibody titers against CPV in Group III indicates widespread contamination of the pathogen within the environment.


Bionote's immunofluorescence analyzer, Vcheck, is designed to generate fast and accurate diagnoses for in-clinic testing through its automative blood testing system that can run 24 quantitative and semi-qualitative tests (NT-proBNP, SDMA, D-dimer, CRP, SAA, cPL, fPL, cCortisol, T4, TSH, Progesterone, and Antibody titers).